Seborrheic keratosis
Seborrheic keratosis is a benign growth of immature keratinocytes.
Epidemiology
Seborrheic keratosis is the most common benign skin tumor in adults > 30 years of age.
Etiology
- Associated with activating mutations of the fibroblast growth factor receptor 3.
- SK itself is benign, but rapid onset of numerous SKs (Leser-Trélat sign) is often associated with an internal malignancy (eg, gastric adenocarcinoma), possibly due to overproduction of insulin-like growth factor 1 and other cytokines.
Tip
Don't mix with Mucocutaneous lentigines in Peutz-Jeghers syndrome
Pathophysiology
Clinical features
- Single or multiple soft papules or plaques that appear stuck on
- Located on the trunk, upper extremities, face, and/or scalp
- Texture is greasy, waxy, velvety, or warty
